Biotin and derivatives
![Medchemexpress LLC m-PEG-NHS ester (MW 10000) | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC m-PEG-NHS ester (MW 10000) | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 1 G
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two distinct ligands joined by a linker: one targeting an E3 ubiquitin ligase and the other binding to a specific target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system to degrade target proteins
- Solid, white to off-white appearance
- For research use only
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 g/mol | C54H96N2O29 | 25 MG
Bis-PEG21-NHS ester is a PEG/alkyl/ether-based linker used in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is supplied as a solid with high purity and defined storage recommendations.
- PEG/alkyl/ether-based linker
- Cleavable linker suitable for ADC synthesis
- Used in the construction of PROTAC molecules
- High purity (98.0%)
- Molecular weight 1237.34 g/mol
- CAS number 2221948-98-5
- Powder storage: -20°C for long-term stability
Medchemexpress LLC Heneicosaoxa PEG diacid bis(2,5-dioxo-1-pyrrolidinyl) ester | 2221948-98-5 | MFCD21363289 | 98.0% | 1237.34 g/mol | C54H96N2O29 | 100 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG)-based N-hydroxysuccinimide (NHS) ester linker used for amine conjugation in the synthesis of PROTACs and antibody-drug conjugates. It provides hydrophilicity and spacing between conjugated moieties.
- Bifunctional NHS ester for amine conjugation.
- PEG21 spacer provides hydrophilicity and flexibility.
- Suitable for PROTAC and ADC linker assembly.
- High purity: 98.0%.
- Molecular weight ~1237.34 g/mol.
- Solid powder; store powder at -20°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in lab-scale quantities such as 100 MG.
Medchemexpress LLC TCO-PEG12-NHS ester | 2185016-39-9 | MFCD00012569 | 95.0% | 866.99 | C40H70N2O18 | 10 MG
TCO-PEG12-NHS ester is a PEG-based linker reagent consisting of a trans-cyclooctene (TCO) group connected through a 12-unit polyethylene glycol (PEG12) spacer to an N-hydroxysuccinimide (NHS) ester. It enables efficient amine coupling and rapid tetrazine click chemistry, and is used as a cleavable linker in ADC and PROTAC synthesis for bioconjugation applications.
- Provides a TCO functional group for rapid click reactions.
- PEG12 spacer improves solubility and reduces steric hindrance.
- NHS ester enables efficient coupling to primary amines.
- Suitable for ADC and PROTAC linker construction and general bioconjugation.
- Supplied in small research-scale quantities for conjugation workflows.
Medchemexpress LLC Azido-PEG6-NHS ester | 2055014-64-5 | MFCD22683276 | 98.0% | 476.48 g/mol | C19H32N4O10 | 25 MG
Azido-PEG6-NHS ester is a bifunctional PEG-based reagent containing an azide group for bioorthogonal click chemistry and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines. It is commonly used as a linker in antibody-drug conjugate and PROTAC synthesis, and for general bioconjugation applications.
- Bifunctional: azide for CuAAC/SPAAC and NHS ester for amine coupling.
- PEG6 spacer improves solubility and reduces steric hindrance.
- High purity for reliable conjugation reactions.
- Suitable for ADC and PROTAC linker installation and bioconjugation workflows.
- Available in small-scale packaging compatible with research applications.
![Medchemexpress LLC (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 2,5-dioxopyrrolidin-1-yl carbonate. | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000299394.png-250.jpg)
Medchemexpress LLC (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 2,5-dioxopyrrolidin-1-yl carbonate. | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 100 MG
Endo-BCN-NHS carbonate is a succinimidyl carbonate reagent that installs bicyclo[6.1.0]non-4-yn (BCN) handles onto primary amines, enabling strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click crosslinking. It is used to functionalize proteins and elastin-like polymers for hydrogel formation and cell-encapsulation studies.
- High purity (99.54%).
- Molecular formula C15H17NO5, molecular weight 291.30 g/mol.
- Reacts with primary amines to introduce BCN handles for SPAAC crosslinking.
- Appearance: white to light yellow solid.
- Recommended storage: powder at -20°C; in solvent: -80°C (6 months) or -20°C (1 month).
- Available in multiple package sizes including 100 mg.
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 98.96% | 25 MG
Mal-PEG8-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound is for research use only and aids in the development of PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-NHS (DSPE-NHS) | 1383932-86-2 | MFCD34561791 | 95.0% | 945.2 g/mol | C49H89N2O13P | 10 MG
DSPE-NHS is an N-hydroxysuccinimide (NHS) ester functionalized distearoyl phosphoethanolamine used for bioconjugation and liposome formation. The reagent self-assembles into lipid bilayers in aqueous solution, and the NHS ester reacts selectively with primary amines to form stable amide bonds, enabling antibody labeling and attachment of amine-containing molecules for nanoparticle and drug-delivery applications.
- Reactive NHS ester for covalent coupling to primary amines.
- Self-assembles into lipid bilayers in aqueous solution.
- Enables antibody labeling and protein conjugation.
- Suitable for liposome and nanocarrier preparation.
- Long-term storage recommended at -20 °C, sealed and protected from moisture and light.
![eMolecules 943858-70-6 | Azidobutyric acid NHS ester | Broadpharm | MFCD22573606 | 226.192 | C8H10N4O4 | 95.000 | [N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O | 500mg | 779523831](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000126046.jpg-250.jpg)
eMolecules 943858-70-6 | Azidobutyric acid NHS ester | Broadpharm | MFCD22573606 | 226.192 | C8H10N4O4 | 95.000 | [N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O | 500mg | 779523831
Azidobutyric acid NHS ester | Broadpharm | 943858-70-6 | MFCD22573606 | 226.192 | C8H10N4O4 | 95.000 | [N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O | 500mg | 779523831
Apexbio Technology LLC Sulfo-NHS-SS-11-Biotin 1g
Sulfo-NHS-SS-11-Biotin is an amine-reactive water-soluble biotinylation reagent containing an N-hydroxysulfosuccinimide (Sulfo-NHS) active ester group and a cleavable disulfide bond The Sulfo-NHS moiety reacts specifically with primary amines in proteins peptides or other biomolecules forming stable amide linkages This reagent introduces a disulfide-containing spacer arm enabling subsequent selective cleavage under reducing conditions for release of biotinylated molecules It is commonly employed in affinity chromatography immunoprecipitation experiments cell surface protein labeling and target identification allowing isolation purification or detection of biomolecules through streptavidin or avidin affinity interactions